September 27 – 28th 2021

3rd International Conference On Matrix Vesicles: From Biochemistry to Clinic

Nencki Institute of Experimental Biology, Warsaw (Poland)


Synopsis

Matrix vesicles (MVs) are a specific class of extracellular vesicles with diameter between 100 to 300 nm. They are blebbed, under physiological conditions, from hypertrophic chondrocytes during endochondral ossification, from osteoblasts during intramembranous ossification and/or from odontoblasts during dentin formation. MVs, by accumulating calcium and phosphate, can start the initial steps of nucleation of crystals leading to formation of apatite. MVs are enriched in alkaline phosphatase, the enzyme responsible for the hydrolysis of pyrophosphate, an inhibitor of apatite formation. Once apatites are formed, they are released from MVs to the extracellular matrix in the vicinity of the collagen fibers due to strong association of MVs with collagen. Other non-skeletal cells, such as smooth muscle cells, are able to release MVs, leading to vascular calcification.

The following topics will be discussed during the conference: mechanisms of MVs release by mineralization competent cells; accumulation of calcium and phosphate in MVs; the biochemical and biophysical properties of MVs; the functions of MVs in norm and pathology; clinical applications of MVs; proteoliposomes mimicking MVs in nanomedicine.

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Registration system

Participants: 120 (x from Nencki)

Lectures: 10 (2 from Nencki)

Short communications: 16 (x from Nencki)

Catering

During registration and coffee breaks:

Participants: 120 (x from Nencki)

Gallery Hall

Company: Dwór Dłużniewo

Hall A and B

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